
What Is a Manual Ampoule Flame Sealing Machine
A manual ampoule flame sealing machine is a pharmaceutical packaging device used to seal glass ampoules by heating the ampoule neck with a controlled flame, ensuring airtight and sterile closure. The ampoule is rotated manually during heating to allow the neck to receive heat evenly, producing smooth, uniform sealing. This results in ampoules that are visually neat and aesthetically pleasing. The operation is convenient, requires no special skills, and is quick to learn, making it ideal for schools, laboratories, and small-batch pharmaceutical factories.
Working Principle
The machine generates a uniform and concentrated flame through controlled gas combustion. By rotating the ampoule during heating, the glass neck softens evenly. Once softened, the ampoule forms a smooth, airtight sealed finish after separation.
Comparison: Traditional vs. Integrated Design:
Traditional Ampoule Sealing Machines:
- Separate control box and sealing table
- Temporary connection of combustion air pipes required
- Inconvenient positioning and adjustment
- Difficult to store and transport after use
- Accessories easily misplaced or mismatched
RF-1 Integrated Ampoule Sealing Machine:
- One-piece integrated structure
- Combustion air pipe pre-installed
- Only gas or LPG connection required
- Stable flame adjustment and smooth sealing
- Easy preparation, storage, and transportation

Operating Instructions / How to Use
- Connect the gas supply pipe to the gas inlet located at the lower right needle valve of the mixing tee on the back of the machine.
- Plug in the power cord into the upper right socket on the back of the machine.
- Turn on the power switch located at the upper right corner on the front panel.
- Slowly open the gas needle valve until the burner ignites.
- Slowly open the combustion air needle valve (located at the lower left on the back of the machine) until both burners produce long, thin blue flames. The longer and thinner the flame, the better the sealing performance.
- Place an empty ampoule on the tray first. Do not immediately place it into the flame. Check whether the flame is aligned with the center of the tray and positioned at the required sealing height. The height can be adjusted by loosening one adjustment knob on the bracket and tightening it after positioning.
- Place the ampoule filled with liquid medicine at the center of the tray and flame. Rotate the ampoule slowly and evenly with the left hand. When the ampoule neck becomes red-hot, use tweezers with the right hand to pull off the upper part to complete sealing.
- After finishing operation, first close the combustion air valve, and then close the gas valve.
Products Description
Technical Parameters
|
Item |
Specification |
|
Model |
RF-1 Ampoule Sealing Machine |
|
Applicable Ampoule Type |
Pharmaceutical glass ampoules |
|
Ampoule Capacity |
No specific volume limitation |
|
Production Capacity |
600–800 ampoules/hour |
|
Voltage |
220 V |
|
Power |
7 W |
|
Combustion Gas Pressure |
≥0.04 KPa |
|
Fuel Type |
Gas / LPG |
|
Packing Size |
300 × 180 × 350 mm |
|
Net Weight |
3.2 kg |
Standard & Optional Accessories
Standard Accessories:
1 × Main Unit
1 × Stainless Steel Tweezers
2 × Stainless Steel Clamps
1 × 1.5-meter Power Cord
1 × User Manual
1 × 1.5-meter Gas Hose
1 × Gas Pressure Regulator
Additional Notes:
The machine is currently available in 110V and 220V power supply options.
Comparison of Different Models
| Item | RF-1 Manual Ampoule Sealing Machine | GBS-1 Automatic Bottle Rotating Sealer | OHYH-200A Hydrogen-Oxygen Ampoule Sealer |
|---|---|---|---|
| Sealing Method | Gas flame sealing (manual operation) | Gas flame sealing with automatic bottle rotation | Hydrogen-oxygen flame sealing |
| Applicable Ampoule Size | 1–20 ml | Ampoules / tubular glass bottles (small size) | 1–20 ml |
| Fuel / Gas Type | LPG or natural gas | LPG / natural gas + built-in air generator | Hydrogen-oxygen gas (generated by electrolysis) |
| Operation Type | Manual rotation & sealing | Semi-automatic, bottle rotates automatically | Manual sealing with high-temperature flame |
| Production Capacity | 600–800 pcs/hour | 600 pcs/hour | Depends on operator |
| Flame Characteristics | Uniform flame, smooth sealing | Concentrated flame, stable and uniform | High-temperature flame (2800–3000°C) |
| Power Supply | 220V | 110V / 220V (global use) | 220V |
| Power Consumption | 7 W | 25 W | 1000 W |
| Safety Features | Low noise, simple structure | Automatic rotation to avoid hand burns | Dual anti-backfire system (dry & wet), auto gas stop |
| Noise Level | No noise | Low noise | Low noise |
| Weight | 3.2 kg | 4.5 kg | 48 kg |
| Dimensions | 300 × 180 × 350 mm | 305 × 205 × 360 mm | 550 × 330 × 450 mm |
| Typical Applications | Hospitals, labs, schools, small pharmaceutical plants | Teaching, labs, R&D, small batch production | Pharmaceutical & chemical plants with GMP requirements |
| Key Advantages | Compact, cost-saving, easy storage, fast sealing | Easy to operate, no training required, uniform sealing | Clean energy, high temperature, GMP compliant |
| Recommended User | Entry-level | Users wanting safer and more consistent sealing | Professional users with higher quality & safety demands |
Test video:
Test video:
Prior to shipping each batch of equipment, we will concurrently record installation functionality verification videos adhering to the standards of the demonstration video on the left. By simulating typical operating conditions (including stripping operation and the entire material separation process), we will conduct actual measurements to validate core performance metrics such as positioning accuracy, operational stability, and material integrity protection. This ensures the delivered equipment meets quality compliance and functional effectiveness requirements.
packing and shipping

Packaging
Before shipment, each RF-1 Ampoule Sealing Machine is photographed for record to ensure all accessories are complete.
The machine is carefully packed with protective sponge cushioning to prevent vibration and damage during transportation, ensuring safe delivery to our customers.
Flexible Shipping & Trade Terms
We can select the most suitable shipping method and trade terms according to your requirements, ensuring a smooth and hassle-free experience for you.
company

Changsha Yiguang Pharmaceutical Machinery Co., Ltd. is a professional manufacturer specializing in the research, development, production, and sales of pharmaceutical and packaging equipment.
Established in 2014, the company focuses on providing reliable and efficient solutions for the pharmaceutical industry, with a comprehensive product portfolio including ampoule filling and sealing machines, vial filling and capping machines, liquid bottle filling machines, capsule machines, tablet machines, packaging machines, and other customized pharmaceutical equipment.
With nearly 10 years of continuous development, Yiguang has successfully served over 1,000 laboratories and production facilities, including pharmaceutical manufacturers, universities, and government institutions, earning wide recognition for product quality and technical expertise.
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